It is on the World Health Organization's List of Essential Medicines
Medscape - Indication-specific dosing for Zyvox (linezolid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules
Linezolid has been shown to be active against multiresistant pathogens and to have good efficacy in the treatment of serious Gram-positive infections
Linezolid is a member of the oxazolidinone class that inhibits the synthesis of bacterial peptides by binding to the peptidyl transferase center of the 50S ribosome
It will not
Linezolid is an oxazolidinone-class antibacterial indicated in adults and children for the treatment of the following infections caused by susceptible Gram-positive
AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase
This drug should be used during pregnancy only if clearly needed and the benefit outweighs the risk to the fetus
[1-3] Limited data indicate that the maximum dose an infant would receive through
Coadministration of ozanimod with MAO-B inhibitors may decrease exposure of the active metabolites of ozanimod, which may inhibit MAO
Linezolid is the only licensed member of the new group of synthetic antimicrobials within the class oxazolidinones that have activity against most Gram-positive bacteria and mycobacteria
Dose: 30 mg/kg/day PO/IV divided q8h x14-28 days; Info: limit tyramine food content <100 mg/meal; VREF = vancomycin-resistant Enterococcus faecium
Thus, linezolid has the potential for causing serotonin syndrome Serotonin Syndrome Serotonin syndrome is a potentially life-threatening condition resulting from increased central nervous system serotonergic activity that is
Resistance to linezolid can develop with prolonged treatment or if the dose is less than that recommended
06-fold (in rabbits) the expected human exposure level, based on AUCs
For solution Linezolid: a review of its properties, function, and use in critical care
ZYVOX Tablets for oral administration contain 400 mg or 600 mg linezolid as film-coated compressed tablets
Clostridium difficile associated diarrhea seems to be an uncommon complication of linezolid use (0
4 CONTRAINDICATIONS
Drug interactions, dosage, and pregnancy and breastfeeding information should be reviewed before taking this ZYVOX is an oxazolidinone-class antibacterial indicated in adults and children for the treatment of the following infections caused by susceptible Gram-positive bacteria: Nosocomial pneumonia (); Community-acquired pneumonia (); Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis
Additional adverse reactions reported from post-marketing experience are included in the table with frequency category 'Not Teratogenic Effects – Pregnancy Category C
It These highlights do not include all the information needed to use ZYVOX safely and effectively