Both clotrimazole 500mg pessary and clotrimazole 1% cream contain an antifungal called clotrimazole and they work to kill the overgrowth fungus Candida albicans in or around your vaginal area. It can be used to treat the external symptoms of thrush (vulval candidiasis) and may also be used by the woman’s sexual partner to treat associated penile thrush (candidial balanitis)