We randomly assigned 213 patients with cirrhosis and portal hypertension (minimal hepatic venous pressure gradient [HVPG] of 6 mm Hg) to receive timolol, a nonselective beta-blocker (108 patients), ) in which carvedilol can be used as primary antihypertensive agent at
Based on the current evidence, clinicians should consider using low-dose
The 2017 guidelines from the American College of Cardiology/American Heart Association Task Force on Clinical Practice and the Heart Rhythm Society recommend carvedilol (immediate- or
In addition, the variceal bleeding rate, hepatic decompensation rate and
Enter into a variceal eradication programme - discuss with gastroenterologist
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The recommended starting dose of COREG is 6
View carvedilol information, including dose, uses, side-effects, pregnancy, breast feeding, contra-indications and monitoring requirements
At a mean follow-up of 19
5 mg once daily will be maintained if systolic blood pressure does not fall below 90 mm Hg and HR 50 beats per minute
Carvedilol at low doses (6
It was administered intragastrically at the dose of 10 mg/kg of carvedilol per kg of animal weight
If this dose is tolerated, using standing systolic pressure measured about 1 hour after dosing as a guide, the dose should be maintained for 7 to 14 days, and then increased to 12
The recommended starting dose of carvedilol for portal Carvedilol is as efficacious and safe as standard-of-care interventions for the primary and secondary prevention of variceal bleeding
Carvedilol was associated with lower all-cause mortality compared to EVL (3 RCTs, RR 0
This requires a day-case admission for each dose increase
More studies are needed to make firm conclusions
Randomized controlled trial of carvedilol versus variceal band ligation for the prevention of the first variceal bleed
May double the dose every 2 weeks to the highest dose tolerated by patient
Study protocol for a randomised controlled trial of carvedilol versus variceal band ligation in primary prevention of variceal bleeding in Background: Upper variceal bleeding (UVB) is a possible complication of portal hypertension secondary to hepatosplenic schistosomiasis (HSS)